Aylesbury will be without Austin Greenlee, Paul Gregory, Chris Hunter, Graham Thwiates and Tim Atcheson for the first game of the season.
League Debuts for Jeremy Kiely and Stu Gray are likely. Aylesbury also have Ben Woodford and Clive Chandler available for the first time this season.
Last meeting between the two sides was both teams last competitive match on the final day of last season where Aylesbury emerged victorious with a 6-0 home win. Goals from Ollie Hassall x2, Owen Heale, Austin Greenlee, Theo Muth and Dan Lindars.
But with Aylesbury a new look side and key senior members missing, Newbury will feel they have a chance of revenge from the April fixture.
1.30 @ RAF Halton on Saturday